What Is Islet Cell Transplant For Type1 Diabetes? - Dr. Anantharaman Ramakrishnan [cf669d]

2025-07-26

Post Time: 2025-07-26

Dehydration, a common issue affecting millions worldwide, has been linked to various health concerns. While its impact on physical performance is well-documented, dehydration's effect on blood sugar levels often goes unnoticed. In this article, we'll explore the connection between dehydration and high blood sugar levels.

What Causes Dehydration to Affect Blood Sugar?

When the body becomes dehydrated, it fails to regulate its internal environment efficiently. This impaired regulation can disrupt insulin sensitivity, a crucial mechanism for controlling blood sugar levels. Research has shown that even mild dehydration can significantly decrease insulin sensitivity by up to 25% (Source: Journal of Clinical Endocrinology and Metabolism). Insulin resistance makes the body more prone to high blood sugar levels.

How Dehydration Triggers High Blood Sugar

Dehydration's negative impact on blood sugar regulation is multifaceted. Firstly, it can cause an increase in cortisol production – a hormone released during stress that raises glucose levels. This cortisol-induced insulin resistance exacerbates existing metabolic issues and contributes to elevated blood sugar readings (Source: American Journal of Clinical Nutrition). Secondly, dehydration impairs the body's natural mechanism for storing glycogen – its primary energy storage system. When dehydrated, muscles store less glycogen, which in turn leads to increased glucose production by the liver.

The Common Factors Linking Dehydration and Blood Sugar Imbalance

Several factors contribute to dehydration-induced high blood sugar levels:

  • Sweating: High sweating rates during exercise or warm weather further exacerbate dehydration.
  • Hormonal changes: Hormones like cortisol, adrenaline, and insulin work synergistically; however, an imbalance can negatively impact glucose regulation. For instance, increased cortisol production due to dehydration promotes the breakdown of muscle tissue (which releases sugars into circulation), whereas elevated blood sugar suppresses growth hormone secretion – leading to reduced metabolic rate.
  • Medications: Certain medications like diuretics can contribute to dehydration and worsen pre-existing insulin resistance.

Can Drinking Enough Water Help Regulate Blood Sugar?

While it might seem counterintuitive, sufficient hydration has been linked with improved blood sugar control. A study published in the Journal of Clinical Hypertension found that drinking enough water significantly lowers HbA1c levels – a key indicator of long-term glycemic control (Source: American Diabetes Association). Moreover, research indicates that dehydration can impair pancreatic function and lead to an imbalance between glucose uptake into cells.

Staying Hydrated for Better Blood Sugar Management

Proper hydration is crucial for blood sugar regulation. Drinking water regularly throughout the day helps maintain insulin sensitivity – ensuring glucose effectively enters muscles while keeping levels stable in the bloodstream (Source: European Journal of Clinical Nutrition). For optimal results, individuals should consume at least eight 8-ounce glasses of water daily.

Conclusion

Dehydration's adverse effects on blood sugar control can be far-reaching. When our bodies become dehydrated due to various factors such as increased sweating rates during physical activities or hormonal imbalances caused by certain medications, we risk facing complications related directly back toward high levels within one body; however this also happens because other systems get affected while your cells keep working away trying very hard even though they cannot function properly if you are dehydrated.

Islet Cell Transplantation is again a therapy used in Type 1 Diabetes. It used to be an experimental therapy but with growing experience it is entering normal or common place practice. So Islet Cell Transplantation is done in those individuals with repeated low sugars is hypoglycaemias and whose requirement of insulin is so variable that it is difficult for us to manage a patient with subcutaneous insulin therapy or pump. So here what we do is take the pancreas of a dead donors for example if somebody has donated their organs after death, we harvest their pancreas. how do u lower your blood sugar Only the islet cells are removed and those islet cells are processed. After processing they are injected into the liver of the Type 1 Diabetes patient. This insulin producing beta cells gets lodges in the liver and starts producing insulin. So earlier these patients did not have any insulin producing cells. Because when we give it from outside, these patients have insulin producing cells now and these insulin producing cells starts producing insulin just like the native cells of the patient but the problem with Type 1 Diabetes is it is an autoimmune disease. So the autoimmune process that has originally destroyed the beta cells also tries to destroy the beta cells that you have injected the cadaveric beta cells. So what one does in this situation is give immunosuppresion to the patient with Type 1 Diabetes. So along with infusion of insulin producing cells into the liver of the patient, we also give immunosuppresion drug. So which suppresses the immunity in this situation, in some select centres where the processing is excellent there are patients who are insulin free or those who are taking insulin for 3 to 4 times a day, and had a very poor quality of life because the sugar was fluctuating too much. So these individuals are using no insulin at all. About 50% of the what foods increase blood sugar patient become cured of Type 1 Diabetes but it is an invasive procedure requiring insulin infusion to the liver and autoimmune suppression and it does allulose raise blood sugar is not for everyone with Type 1 Diabetes.
What is Islet Cell Transplant for Type1 Diabetes? - Dr. Anantharaman Ramakrishnan
What Is Islet Cell Transplant For Type1 Diabetes? - Dr. Anantharaman Ramakrishnan [cf669d]