How to Manage Nausea from GLP-1 Agonists (Ozempic, Mounjaro)

How to Manage Nausea from GLP-1 Agonists (Ozempic, Mounjaro)

If you're experiencing nausea from GLP-1 agonists like Ozempic (semaglutide) or Mounjaro (tirzepatide), you're not alone. Many people who take these medications for type 2 diabetes or weight management report nausea as a common side effect. Fortunately, there are ways to manage this symptom and make your treatment more tolerable.

Understanding GLP-1 Agonists

GLP-1 agonists are a class of medications that work by mimicking the action of a natural hormone in the body called glucagon-like peptide-1 (GLP-1). This hormone helps regulate blood sugar levels and also slows stomach emptying, which can lead to nausea.

Causes of Nausea

Nausea from GLP-1 agonists is often related to the slowing of stomach emptying. When your stomach takes longer to empty, it can cause feelings of fullness, bloating, and nausea. Other factors that can contribute to nausea include:

  • Starting a new medication
  • Eating before taking your medication
  • Taking your medication on an empty stomach
  • Having other medical conditions or taking other medications that can cause nausea

Managing Nausea

Fortunately, there are several strategies you can try to manage nausea from GLP-1 agonists:

Eat smaller, more frequent meals

Eating smaller meals throughout the day can help slow down stomach emptying and reduce nausea. Focus on nutrient-dense foods like fruits, vegetables, whole grains, and lean proteins.

Choose low-fat or fat-free foods

Fatty foods can slow down stomach emptying even more, making nausea worse. Opt for low-fat or fat-free foods, especially in the morning when you take your medication.

Stay hydrated

Drinking plenty of water can help with nausea and digestion. Aim for at least eight glasses of water a day.

Consider over-the-counter antacids or acid reducers

If you experience heartburn or acid reflux, consider taking an over-the-counter antacid or acid reducer like Tums, Rolaids, or Zantac. However, be sure to talk to your doctor before starting any new medications.

Talk to your doctor about adjusting your dosage

If your nausea is severe, talk to your doctor about adjusting your dosage. They may be able to recommend a lower dose or a different medication that works for you.

Get regular exercise

Regular exercise can help improve digestion and reduce nausea. Aim for at least 30 minutes of moderate-intensity exercise per day.

When to Seek Medical Attention

If you experience any of the following, seek medical attention immediately:

  • Vomiting blood or black tarry stools
  • Difficulty breathing
  • Chest pain or pressure
  • Severe abdominal pain
  • Fever over 101.5°F (38.6°C)

By trying these strategies and talking to your doctor, you can manage nausea from GLP-1 agonists and make your treatment more tolerable.