2025-07-22
Post Time: 2025-07-22
Error: No content files found.๐๐ฎ๐๐ฌ๐๐ซ๐ข๐๐ ๐๐จ๐ซ ๐ ๐จ๐ซ๐ ๐๐ง๐๐จ๐ซ๐ฆ๐๐ญ๐ข๐จ๐ง ๐จ๐ง ๐๐๐๐ฅ๐ญ๐ก ๐ฉโโโ ๐๐ง๐ ๐ ๐๐๐ข๐๐ข๐ง๐๐๐ฉบ๐ ๐๐๐ป๐๐๐ฎ๐ด๐ฟ๐ฎ๐บ : 1. Erectile dysfunction: Introduction: Pharmacology ------------------------------------------------------------------------------------- Erectile dysfunction (ED) is treated using medications that enhance penile blood flow (vasodilation) ๐ฉธ and promote smooth muscle relaxation in the corpus cavernosum, facilitating an erection ๐๐ช. The main classes of drugs include: ๐น Phosphodiesterase-5 (PDE-5) Inhibitors (Sildenafil ๐, Tadalafil, Vardenafil, Avanafil) โ These are the first-line therapy, working by inhibiting PDE-5, an enzyme that degrades cGMP, thereby enhancing nitric oxide (NO) ๐งช effects. This leads to vasodilation, increased blood flow, and improved erection quality. Tadalafil has the longest duration (36 hours โณ), while sildenafil and vardenafil last for 4โ6 hours. Contraindicated with nitrates (e.g., nitroglycerin ๐ซ) due to the risk of severe hypotension. ๐น Prostaglandin E1 (PGE1) Analogs (Alprostadil ๐ฉธ) โ Used in patients unresponsive to PDE-5 inhibitors, administered intracavernosally (injection) or intraurethrally (suppository), directly inducing vasodilation. ๐น Testosterone Replacement Therapy (TRT) ๐งฌ โ Beneficial in hypogonadal men with low testosterone levels, improving libido and erectile function. Administered via gels, injections, or patches. ๐น Dopamine Agonists (e.g., Apomorphine ๐ญ) โ Used for neurogenic ED, stimulating dopamine receptors in the brain to enhance arousal. ๐น Yohimbine ๐ฟ (Alpha-2 Adrenergic Antagonist) โ A herbal supplement that may increase penile blood flow, but its cannabis male enhancement efficacy is inconsistent. ๐น Vacuum Erection Devices & Penile Implants โ Non-pharmacological options for severe or refractory ED. ๐น Lifestyle Modifications โ Regular exercise ๐๏ธ, weight loss ๐ฅ, smoking cessation amitriptyline viagra interaction ๐ญ, and stress reduction ๐ง significantly improve erectile function. A multimodal approach ensures better sexual male enhancement surgeries health, confidence, and quality of life ๐โจ. #ErectileDysfunction #PDE5Inhibitors ๐ #Sildenafil ๐ #Tadalafil #SexualHealth ๐ #TestosteroneTherapy ๐งฌ #Vasodilation ๐ฉธ #MedicalEducation ๐ #MBBSNotes #StudySmart ๐ง #MenHealth ๐๏ธ #NitricOxideEffect ๐ #SafeSexualTherapy #BoostLibido ๐ช