The MidSouth Computational Biology and Bioinformatics Society (MCBIOS) held it’s seventh annual conference on February 19 and 20, 2010 at Arkansas State University in Jonesboro, AR, . The seventh annual conference was presided over by Daniel Berleant, this year’s President of MCBIOS . Keynote speakers were Elaine Ostrander of NIH, renowned for her work on dog genomics, Clayton Naeve, CIO of St. Jude Children's Research Hospital, and Robert Cottingham, Leader of the Computational Biology and Bioinformatics Group, Oak Ridge National Laboratory.
MVSU bioinformatics professors, Dr. Charles Bland and Dr. Abigail S Newsome along with student Aleksandra A Markovets presented their published work "Promoter prediction in E. coli based on SIDD profiles and Artificial Neural Networks." In addition, Markovets gained a third place award for her oral presentation.
The research conducted for the paper focused on solving the challenges faced when attempting to correctly identify promoter regions in biology. Recent studies have shown that DNA structural properties, such as curvature, stacking energy, and stress-induced duplex destabilization (SIDD) are useful in promoter prediction, as well. In this paper, the currently used SIDD energy threshold method is compared to the proposed artificial neural network (ANN) approach for finding promoters based on SIDD profile data.
For full text of paper or abstract, click here.
Links
MidSouth Computational Biology and Bioinformatics Society (MCBIOS)
Midsouth Computational Biology and Bioinformatics (MCBIOS) conference
Promoter prediction in E. coli based on SIDD profiles and Artificial Neural Networks